Periostin in Allergic Inflammation

Periostin promotes chronic allergic inflammation in response to Th2 cytokines.

Allergic inflammation triggered by exposure of an allergen frequently leads to the onset of chronic inflammatory diseases such as atopic dermatitis (AD) and bronchial asthma. The mechanisms underlying chronicity in allergic inflammation remain unresolved. Periostin, a recently characterized matricellular protein, interacts with several cell surface integrin molecules, providing signals for tiss...

Periostin regulates goblet cell metaplasia in a model of allergic airway inflammation.

Periostin is a 90-kDa member of the fasciclin-containing family and functions as part of the extracellular matrix. Periostin is expressed in a variety of tissues and expression is increased in airway epithelial cells from asthmatic patients. Recent studies have implicated a role for periostin in allergic eosinophilic esophagitis. To further define a role for periostin in Th2-mediated inflammato...

Periostin: from pathogenesis to clinical application in allergic diseases.

Allergology International Vol. 63 No. 2 includes a collection of review articles entitled “ Periostin : from pathogenesis to clinical application in allergic diseases”, as well as original articles and letters to the editor. We believe this issue will be of great interest to clinical and basic researchers in this field. Periostin is a protein that has recently been implicated in the pathogenesi...

Periostin as a biomarker of airway inflammation.

Allergic Inflammation

The fine structure of collagen fibrils at sites of antigen-antibody interaction is described. Following injection of antigen (BSA or ferritin) into the center of the cornea of hyperimmune rabbits, an acidophilic ring of precipitate forms at the periphery of the cornea, where antigen and antibody interact in optimal proportions. The precipitate is soon removed by infiltrating polymorphs, but per...